il28b snp genotyping among iranian hcv-infected patients: a preliminary report
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IL28B SNP genotyping among Iranian HCV-infected patients: A preliminary report
At the beginning of the third millennium, Hepatitis C virus (HCV) infection continues to be a major health hazard, with 170 million chronically infected people worldwide (1). Recent research has found that the prevalence of HCV infection in Iran is 1% and 0.1% in males and females, respectively (2). Although a combination of pegylated interferon (PEG-IFN) and ribavirin (RBV) has been establishe...
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BACKGROUND Successful treatment to eliminate HCV RNA depends on the identified genotype. In the present study, we compared the frequency of different HCV genotypes, during four years study (2004 till 2008). METHODS Sera specimens were received from 16 provinces of Iran. We used High Pure Viral Nucleic Acid Purification kit for extraction and samples were tested with improved form of RT-PCR te...
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Latin America is a diverse region with more than 500million people and approximately 8 million HCV infected individuals. The recent description of genetic polymorphisms associated to the interleukin 28B gene that predicts the response to treatment in these patients has impacted the clinical algorithms of management. In this review we examine the studies of prevalence of the IL28B genotypes in t...
متن کاملgenotyping pattern among iranian hcv positive patients
background: successful treatment to eliminate hcv rna depends on the identified genotype. in the present study, we compared the frequency of different hcv genotypes, during four years study (2004 till 2008). methods: sera specimens were received from 16 provinces of iran. we used high pure viral nucleic acid purification kit for extraction and samples were tested with improved form of rt-pcr ...
متن کاملImpact of IL28B-Related Single Nucleotide Polymorphisms on Liver Transient Elastography in Chronic Hepatitis C Infection
BACKGROUND AND AIMS Recently, several genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) in proximity to IL28B predict spontaneous clearance of hepatitis C virus (HCV) infection as well as outcome following pegylated interferon and ribavirin therapy among genotype 1 infected patients. Additionally the presence of the otherwise favorable IL28B genetic varia...
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عنوان ژورنال:
hepatitis monthlyجلد ۱۱، شماره ۵، صفحات ۳۸۶-۳۸۸
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